Autism: A form of lead and mercury toxicity
Environmental Toxicology and Pharmacology
Volume 38, Issue 3, November 2014, Pages 1016-1024
Autism: A form of lead and mercury toxicity
Heba A.Yassa
Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Assiut University, Egypt.
Received 16 July 2014, Revised 7 October 2014, Accepted 10 October 2014, Available online 6 November 2014.
https://doi.org/10.1016/j.etap.2014.10.005
Highlights
• Autism is a developmental disability characterized by severe, pervasive deficits in social interaction and communications.
• Lead and mercury two of the most common heavy metals in the environment.
• Lead and mercury can lead to autistic disorders.
• Many risk factors contribute to the high level of heavy metals in autistic children.
• Defect in the metabolism of the heavy metals in autistic children also contribute to the high level of these heavy metals in their body.
• Chelating agents can be used in the treatment of the autistic disorders.
Abstract
Aim
Autism is a developmental disability characterized by severe deficits in social interaction and communication. The definite cause of autism is still unknown. The aim of this study is to find out the relation between exposure to Lead and/or mercury as heavy metals and autistic symptoms, dealing with the heavy metals with chelating agents can improve the autististic symptoms.
Method
Blood and hair samples were obtained from 45 children from Upper Egypt with autism between the ages of 2 and 10 years and 45 children served as controls in the same age range, after taken an informed consent and fill a questionnaire to assess the risk factors. The samples were analyzed blindly for lead and mercury by using atomic absorption and ICP-MS. Data from the two groups were compared, then follow up of the autistic children after treatment with chelating agents were done.
Results
The results obtained showed significant difference among the two groups, there was high level of mercury and lead among those kids with autism. Significant decline in the blood level of lead and mercury with the use of DMSA as a chelating agent. In addition, there was decline in the autistic symptoms with the decrease in the lead and mercury level in blood.
Conclusion
Lead and mercury considered as one of the main causes of autism. Environmental exposure as well as defect in heavy metal metabolism is responsible for the high level of heavy metals. Detoxification by chelating agents had great role in improvement of those kids.
