Regression

A trend or shift toward a lower or less perfect state such as gradual loss of memories and acquired skills, or reversion to an earlier mental or behavioral level. – Merriam-Webster

Regression

Prevalence and Age of Onset of Regression in Children with Autism Spectrum Disorder: A Systematic Review and Meta-analytical Update

LAY SUMMARY: About a third of children with Autism Spectrum Disorder experience loss of skills, which is also known as autistic regression. This paper provides an update of the rate of autistic regression in children and the age when they first experience loss of skills, based on current studies. The findings from this review contribute to our understanding of the onset patterns of autistic regression. Unfortunately, studies are not sufficiently similar, making it difficult to provide clear answers on the exact timing or type of regression seen in different children.

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  • March 14, 2021
AHRQ / Contaminants / Epidemiology / Hepatitis A Vaccine / Human Fetal Cell Lines / MMR / Regression / Time Trends / Varicella Vaccine

Impact of environmental factors on the prevalence of autistic disorder after 1979

Excerpt:
“Autistic disorder change points years are coincident with introduction of vaccines manufactured using human fetal cell lines, containing fetal and retroviral contaminants, into childhood vaccine regimens. This pattern was repeated in the US, UK, Western Australia and Denmark. Thus, rising autistic disorder prevalence is directly related to vaccines manufactured utilizing human fetal cells. Increased paternal age and DSM revisions were not related to rising autistic disorder prevalence.”

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  • September 1, 2014
Amygdala / Cytokines / Dendritic cells / GI / Glial Cells / Immune / Inflammation / Regression

Myeloid dendritic cells frequencies are increased in children with autism spectrum disorder and associated with amygdala volume and repetitive behaviors

Excerpt:
“Dendritic cells play key roles in modulating immune responses and differences in frequencies or functions of these cells may result in immune dysfunction in children with ASD. These data further implicate innate immune cells in the complex pathophysiology of ASD.”

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  • July 16, 2013

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