INTERPRETATION:
Our findings suggest that predisposition to autoimmunity, and immune/inflammatory activation, may be associated with autistic regression.
- April 6, 2017
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For the term "diabetes".
20 Papers / ASD Subtypes / Autism Biomarkers / Autoimmunity / Genes / GI / Glial Cells / Immune / Neuroinflammation / Post-mortem / Review
Excerpts:
“In our clinical work and review of the literature, we have been impressed by the possible role of autoimmune disorders as influencing the pathophysiology of a distinct, objectively defined etiologic subtype of ASDs.”
“The notion that environmental factors contribute to ASD prevalence continues to evolve. Once-influential theories suggesting links among exposure to vaccines containing attenuated virus or toxins, conditions such as inflammatory bowel disease, and ASDs have fallen from favor since the retraction of a key study (Wakefield et al, 1998). It is important to emphasize, however, that the major reason for retraction was poor scientific method rather than theoretical flaws. Although ASDs are currently within the realm of psychiatrists and neurologists, it is becoming clear that at least some subtypes represent whole-body disorders, offering exciting new possibilities for therapy.”
- November 13, 2012
Excerpt:
“In November 1989, IOM established the Committee to Review the Adverse Consequences of Pertussis and Rubella Vaccines. The specific charge to the committee, as outlined in Section 312 of the National Childhood Vaccine Injury Act, was to: identify and review all available medical and scientific literature on the nature, circumstance, and extent of the relationship, if any, between vaccines containing pertussis (including whole cells, extracts, and specific antigens) and the following illnesses and conditions: hemolytic anemia, hypsarrhythmia, infantile spasms, Reye syndrome, peripheral mononeuropathy, deaths classified as sudden infant death syndrome (SIDS), aseptic meningitis, juvenile diabetes, autism, learning disabilities, hyperactivity, and other such illnesses as recommended by the committee or the Advisory Commission on Childhood Vaccines”
“Summary
No data were identified that address the question of a relation between vaccination with DPT or its pertussis component and autism. There are no experimental data bearing on a possible biologic mechanism.
Conclusion
There is no evidence to indicate a causal relation between DPT vaccine or the pertussis component of DPT vaccine and autism.”
- January 1, 1991
Abstract
A family is presented to demonstrate the rare phenomenon of early infantile autism in the presence of autoimmune disease. The youngest son in the family has a multiple diagnosis of autism, Addison’s disease, and moniliasis. The next older brother has hypoparathyroidism, Addison’s disease, moniliasis, and diabetes mellitus. The next older brother has hypoparathyroidism, Addison’s disease, moniliasis, and alopecia totalis. The oldest son and first born child in this family of four is, along with the parents, symptom free. Whereas autism in the youngest son might be attributed to the traumatic family situation, in which there exists the constant threat of near-death, it might conceivably be attributed also to a primary effect of autoimmune impairment from the formation of autoantibodies affecting the central nervous system.
- June 1, 1971
