Excerpt: “Our findings that DCs primarily express the RyR1 channel complex and that this complex is uncoupled by very low levels of THI with dysregulated IL-6 secretion raise intriguing questions about a molecular basis for immune dyregulation and the possible role of the RyR1 complex in genetic susceptibility of the immune system to mercury.”
“Dendritic cells are exquisitely sensitive to Thimerosal, with one mechanism involving the uncoupling of positive and negative regulation of Ca2+ signals contributed by RyR1.”
- March 16, 2006
