INTERPRETATION:
Our findings suggest that predisposition to autoimmunity, and immune/inflammatory activation, may be associated with autistic regression.
- April 6, 2017
Febrile seizures
A febrile seizure is a convulsion in a child caused by a spike in body temperature, often from an infection. – Mayo Clinic
Excerpts:
“Febrile seizures represent a serious adverse event following measles, mumps and rubella (MMR) vaccination.”
“In conclusion, using detailed health register information on vaccinations and febrile seizure episodes, we identified common variants at two loci associated with febrile seizures as an adverse event following MMR vaccination. From a public health perspective, it is essential to study the underlying causes of any serious adverse event of the MMR vaccine, a preventive pharmaceutical product given to millions of children each year, and our findings provide important leads for further research in the fields of immunogenetics and vaccinology. Concomitantly, we identified four loci associated with febrile seizures in general, which together with supporting evidence from electrophysiological experiments underline the importance of altered ion channel function in this common childhood disorder. Further functional studies will illuminate the biological mechanisms behind the associations reported here and might also provide more general insights into mechanisms of epileptogenesis and neuronal hyperexcitability.”
- October 26, 2014
Excerpt:
“This study suggests that febrile seizures and family history of neuropsychiatric disorders are correlated with autistic regression.”
- January 30, 2012
Excepts:
“There were an additional 20 febrile seizures for every 100,000 vaccinated at 12 months.”
“CONCLUSIONS:
There are significantly elevated risks of primarily emergency room visits approximately one to two weeks following 12 and 18 month vaccination. Future studies should examine whether these events could be predicted or prevented.”
- December 12, 2011
CONCLUSIONS:
Among 12- to 23-month-olds who received their first dose of measles-containing vaccine, fever and seizure were elevated 7 to 10 days after vaccination. Vaccination with MMRV results in 1 additional febrile seizure for every 2300 doses given instead of separate MMR + varicella vaccines. Providers who recommend MMRV should communicate to parents that it increases the risk of fever and seizure over that already associated with measles-containing vaccines.
- July 1, 2010
Excerpts:
“The association of epilepsy, autism spectrum disorders (ASD), and intellectual disability (ID) is well recognized.”
“CONCLUSIONS:
MMR vaccination was associated with a transient increased rate of febrile seizures…”
- July 21, 2004
