Vaccine adverse events

Adverse event following a vaccine.

20 Papers / Aluminum / CRPS / Cytokines / Fever / Glial Cells / HPV vaccine / IL-1β / IL-6 / Immune / Inflammation / Mercury / Neuroinflammation / Review / ROS / TNF-α / Vaccine adverse events

Post-vaccination inflammatory syndrome: a new syndrome

Except:
“There is a growing body of work to support the role of inflammatory cytokines in ASD. An emerging focus of research into the etiology of ASD has suggested neuroinflammation as one of the major candidates underlying the biologica model [5]. Plasma levels of IL-1β, IL-6 and IL-8 were increased in children with ASD and correlated with regressive autism, as well as impaired communication and aberrant behavior [6-8]. Vargas [9] showed an active neuroinflammatory process in the cerebral cortex, white matter, and in the cerebellum of autistic patients. Immunocytochemichal studies showed marked activation of microglia [5].”

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  • January 1, 2019
Blood brain barrier / Cytokines / Hepatitis B Vaccine / IL-4 / Inflammation / Neuroinflammation / Vaccine adverse events / Vaccine Schedule

IL-4 mediates the delayed neurobehavioral impairments induced by neonatal hepatitis B vaccination that involves the down-regulation of the IL-4 receptor in the hippocampus

Excerpt:
“This finding suggests that clinical events concerning neonatal IL-4 over-exposure, including neonatal hepatitis B vaccination and allergic asthma in human infants, may have adverse implications for brain development and cognition.”

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  • October 22, 2018
Adjuvant / Aluminum / Autoimmunity / IL-4 / IL-6 / Immune / T cell / Vaccine adverse events

A role for impaired regulatory T cell function in adverse responses to aluminum adjuvant-containing vaccines in genetically susceptible individuals

Abstract

Regulatory T cells play a critical role in the immune response to vaccination, but there is only a limited understanding of the response of regulatory T cells to aluminum adjuvants and the vaccines that contain them. Available studies in animal models show that although induced T regulatory cells may be induced concomitantly with effector T cells following aluminum-adjuvanted vaccination, they are unable to protect against sensitization, suggesting that under the Th2 immune-stimulating effects of aluminum adjuvants, Treg cells may be functionally compromised. Allergic diseases are characterized by immune dysregulation, with increases in IL-4 and IL-6, both of which exert negative effects on Treg function. For individuals with a genetic predisposition, the beneficial influence of adjuvants on immune responsiveness may be accompanied by immune dysregulation, leading to allergic diseases. This review examines aspects of the regulatory T cell response to aluminum-adjuvanted immunization and possible genetic susceptibility factors related to that response.

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  • July 26, 2014
20 Papers / Acetaminophen / Adjuvant / Aluminum / CDC / Fever / Glutathione / Immune / Measles / Mercury / MMR / Review / Toxicants / Vaccine adverse events

Empirical Data Confirm Autism Symptoms Related to Aluminum and Acetaminophen Exposure

Excerpt:
“We propose that children with the autism diagnosis are especially vulnerable to toxic metals such as aluminum and mercury due to insufficient serum sulfate and glutathione. A strong correlation between autism and the MMR (Measles, Mumps, Rubella) vaccine is also observed, which may be partially explained via an increased sensitivity to acetaminophen administered to control fever.”

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  • November 7, 2012
Adjuvant / Aluminum / Apoptosis / Hepatitis B Vaccine / Mitochondria / Toxicants / Vaccine adverse events

Hepatitis B vaccine induces apoptotic death in Hepa1-6 cells

Excerpt:
‘We conclude that exposure of Hepa1-6 cells to a low dose of adjuvanted hepatitis B vaccine leads to loss of mitochondrial integrity, apoptosis induction, and cell death, apoptosis effect was observed also in C2C12 mouse myoblast cell line after treated with low dose of vaccine (0.3, 0.1, 0.05 μg/ml).”

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  • January 17, 2012
Febrile seizures / MMR / Seizure / Vaccine adverse events

Adverse Events following 12 and 18 Month Vaccinations: a Population-Based, Self-Controlled Case Series Analysis

Excepts:
“There were an additional 20 febrile seizures for every 100,000 vaccinated at 12 months.”

“CONCLUSIONS:
There are significantly elevated risks of primarily emergency room visits approximately one to two weeks following 12 and 18 month vaccination. Future studies should examine whether these events could be predicted or prevented.”

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  • December 12, 2011
20 Papers / Encephalopathy / Immune / Mercury / Review / Thimerosal / Toxicants / Vaccine adverse events / Vaccine Schedule

Neurological adverse events associated with vaccination

Excerpt:
“Among the “major” neurological complications, usually manifesting more than 48 hours after vaccination and which might be the cause of permanent damage to the central nervous system (CNS), the following are listed: seizures – especially if there is no increase in body temperature, hypotonic-hyporesponsive episodes, postvaccinal encephalitis, postvaccinal encephalopathy [6, 8-11] and autism [10, 12-14].”

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  • June 24, 2002
Adjuvant / DTaP / Hypotonia / Mercury / MMR / Pertussis vaccine / Seizure / Thimerosal / Toxicants / Vaccine adverse events

Neurological adverse events associated with vaccination

Abstract

Public tolerance to adverse reactions is minimal. Several reporting systems have been established to monitor adverse events following immunization. The present review summarizes data on neurologic complications following vaccination, and provides evidence that indicates whether they were directly associated with the vaccines. These complications include autism (measles vaccine), multiple sclerosis (hepatitis B vaccine), meningoencephalitis (Japanese encephalitis vaccine), Guillain-Barré syndrome and giant cell arteritis (influenza vaccine), and reactions after exposure to animal rabies vaccine. Seizures and hypotonic/hyporesponsive episodes following pertussis vaccination and potential risks associated with varicella vaccination, as well as vaccine-associated paralytic poliomyelitis following oral poliovirus vaccination, are also described. In addition, claims that complications are caused by adjuvants, preservatives and contaminants [i.e. macrophagic myofasciitis (aluminium), neurotoxicity (thimerosal), and new variant Creutzfeldt-Jakob disease (bovine-derived materials)] are discussed.

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  • June 7, 2002

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