DTaP / Tetanus / Vagus Nerve

Autism and clostridium tetani

Excerpt:
“The vagus nerve is capable of transporting tetanus neurotoxin (TeNT) and provides a route of ascent from the intestinal tract to the CNS. This route bypasses TeNT’s normal preferential binding sites in the spinal cord, and therefore the symptoms of a typical tetanus infection are not evident. Once in the brain, TeNT disrupts the release of neurotransmitters by the proteolytic cleavage of synaptobrevin, a synaptic vesicle membrane protein. This inhibition of neurotransmitter release would explain a wide variety of behavioral deficits apparent in autism. Lab animals injected in the brain with TeNT have exhibited many of these behaviors. Some children with autism have also shown a significant reduction in stereotyped behaviors when treated with antimicrobials effective against intestinal clostridia.

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  • August 1, 1998
GI

Abnormal intestinal permeability in children with autism

Abstract

We determined the occurrence of gut mucosal damage using the intestinal permeability test in 21 autistic children who had no clinical and laboratory findings consistent with known intestinal disorders. An altered intestinal permeability was found in 9 of the 21 (43%) autistic patients, but in none of the 40 controls. Compared to the controls, these nine patients showed a similar mean mannitol recovery, but a significantly higher mean lactulose recovery (1.64% +/- 1.43 vs 0.38% +/- 0.14; P < 0.001). We speculate that an altered intestinal permeability could represent a possible mechanism for the increased passage through the gut mucosa of peptides derived from foods with subsequent behavioural abnormali

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  • September 1, 1996
Pertussis vaccine

Adverse Effects of Pertussis and Rubella Vaccines: A Report of the Committee to Review the Adverse Consequences of Pertussis and Rubella Vaccines

Excerpt:
“In November 1989, IOM established the Committee to Review the Adverse Consequences of Pertussis and Rubella Vaccines. The specific charge to the committee, as outlined in Section 312 of the National Childhood Vaccine Injury Act, was to: identify and review all available medical and scientific literature on the nature, circumstance, and extent of the relationship, if any, between vaccines containing pertussis (including whole cells, extracts, and specific antigens) and the following illnesses and conditions: hemolytic anemia, hypsarrhythmia, infantile spasms, Reye syndrome, peripheral mononeuropathy, deaths classified as sudden infant death syndrome (SIDS), aseptic meningitis, juvenile diabetes, autism, learning disabilities, hyperactivity, and other such illnesses as recommended by the committee or the Advisory Commission on Childhood Vaccines”

“Summary

No data were identified that address the question of a relation between vaccination with DPT or its pertussis component and autism. There are no experimental data bearing on a possible biologic mechanism.
Conclusion

There is no evidence to indicate a causal relation between DPT vaccine or the pertussis component of DPT vaccine and autism.”

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  • January 1, 1991
Opioid

Role of neuropeptides in autism and their relationships with classical neurotransmitters.

Abstract
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Abstract

Outlines how excessive levels of opioids in the central nervous system (CNS) affect and modify the classical neurotransmission systems and result in some of the perceptual, social, and behavioral difficulties that define autism. Preliminary results of urinary peptide analysis, by high-pressure liquid chromatography, showed marked differences between 25 autistic and 20 normal Ss (aged 18–50 yrs). Most Ss with the fragile-X-chromosomal abnormality had a similar, characteristic but distinct peptide abnormality as did a smaller subgroup of Ss with Down’s syndrome and nonspecific mental handicaps.”

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  • January 1, 1990
Opioid

A neurochemical theory of autism

Excerpt: “autism is an emotional disturbance arising from an upset in the opiate systems in the brain, and hence proposes, as a possibility, opiate antagonist therapy for the autistic syndrome.”

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  • January 1, 1979

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