Review

A survey of previously published research on a topic.

Review

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The American Academy of Pediatrics FALSELY states that “Vaccines are not associated with autism.”

Following is a list of abstracts from 234 papers demonstrating the multiple associations between vaccines and autism.

Autism is a largely immune mediated condition, and the purpose of a vaccine is to change the behavior of the immune system. Vaccines and their ingredients can cause the underlying medical conditions that are commonly found in children who have been given an autism diagnosis. These conditions include immune system impairment, autoimmune conditions, neuroinflammation, gastrointestinal damage, neurological regression, mitochondrial dysfunction, oxidative stress, glial cell activation, interleukin-6 secretion dysregulation, damage to the blood–brain barrier, seizures, dendritic cell dysfunction, mercury poisoning, aluminum toxicity, gene activation and alteration, glutathione depletion, impaired methylation, impaired thioredoxin regulation, impairment of the opioid system, cellular apoptosis, endocrine dysfunction, and other disorders.

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  • April 6, 2023
20 Papers / 3 Studies / Adjuvant / Aluminum / Autophagy / Blood brain barrier / Cytokines / Dendritic cells / Genes / Glial Cells / IL-6 / Immune / Inflammation / Neuroinflammation / Oxidative Stress / Review / Toxicants

Inflammation and Autophagy: A Convergent Point between Autism Spectrum Disorder (ASD)-Related Genetic and Environmental Factors: Focus on Aluminum Adjuvants

Excerpts:
“As a result of these pieces of evidence (epidemiological, clinical and preclinical data) pointing to a potential causal association between early ABA (aluminum-based adjuvants) exposure and increased ASD risk, new hypotheses regarding neurological and immunological consequences of ABA-containing vaccines and novel clinical strategies (i.e., postponing of ABA-containing vaccines and replacement of ABAs with calcium phosphate are now being considered.“

“Our review presents the lack of fundamental scientific data demonstrating that Al adjuvants are safe and do not induce any long-term side effects. It also supports further investigation related to the effects of early Al adjuvant exposures occurring in combination with genetic susceptibility factors, including autophagy, immune and inflammation process genes. As accumulating evidence shows that modulating the levels of autophagy may increase the risk of NDDs, such studies will elucidate a new etiology for these complex disorders and contribute to develop potential new diagnostic and therapeutic tools.”

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  • August 31, 2022
20 Papers / Aluminum / CRPS / Cytokines / Fever / Glial Cells / HPV vaccine / IL-1β / IL-6 / Immune / Inflammation / Mercury / Neuroinflammation / Review / ROS / TNF-α / Vaccine adverse events

Post-vaccination inflammatory syndrome: a new syndrome

Except:
“There is a growing body of work to support the role of inflammatory cytokines in ASD. An emerging focus of research into the etiology of ASD has suggested neuroinflammation as one of the major candidates underlying the biologica model [5]. Plasma levels of IL-1β, IL-6 and IL-8 were increased in children with ASD and correlated with regressive autism, as well as impaired communication and aberrant behavior [6-8]. Vargas [9] showed an active neuroinflammatory process in the cerebral cortex, white matter, and in the cerebellum of autistic patients. Immunocytochemichal studies showed marked activation of microglia [5].”

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  • January 1, 2019
Antioxidant / Genes / GI / Immune / Inflammation / Methylation / Oxidative Stress / Review

Early Disruption of the Microbiome Leading to Decreased Antioxidant Capacity and Epigenetic Changes: Implications for the Rise in Autism

Excerpt:
“In this review article, we examine the connections between early disruption of the developing microbiome and gastrointestinal tract function, with particular regard to susceptibility to autism. The biological mechanisms that accompany individuals with autism are reviewed in this manuscript including immune system dysregulation, inflammation, oxidative stress, metabolic and methylation abnormalities as well as gastrointestinal distress.”

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  • August 15, 2018
Review / Time Trends

California Autism Prevalence Trends from 1931 to 2014 and Comparison to National ASD Data from IDEA and AD

Abstract

Time trends in U.S. autism prevalence from three ongoing datasets [Individuals with Disabilities Education Act, Autism and Developmental Disabilities Monitoring Network, and California Department of Developmental Services (CDDS)] are calculated using two different methods: (1) constant-age tracking of 8 year-olds and (2) age-resolved snapshots. The data are consistent across methods in showing a strong upward trend over time. The prevalence of autism in the CDDS dataset, the longest of the three data records, increased from 0.001% in the cohort born in 1931 to 1.2% among 5 year-olds born in 2012. This increase began around ~ 1940 at a rate that has gradually accelerated over time, including notable change points around birth years 1980, 1990 and, most recently, 2007.

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  • July 5, 2018
20 Papers / ASD Subtypes / Autism Biomarkers / Autoimmunity / Cytokines / GI / Immune / Inflammation / Males / Parental reports / Review / Seizure

Another Step Toward Defining an Immune-Mediated Subtype of Autism Spectrum Disorder

Excerpts:

“The likelihood of the child having ASD more than doubled among children with food allergy compared with those without food allergy; children with respiratory and skin allergy were also significantly more likely to have ASD, but at a lesser magnitude. While no sex difference was found for food allergy, boys with ASD were significantly more likely than girls with ASD to have respiratory and skin allergy.”

” It may be that GI dysfunction, seizures, and sleep disorder, in addition to food, respiratory, and skin allergies, are medical comorbidities that characterize the immune-mediated subtype of ASD.”

“In the Discussion section of their article, Xu and colleagues review other aspects of immune dysfunction reported in ASD, including abnormalities in peripheral immunoglobulins, imbalance of T-cell subsets, and increased levels of proinflammatory cytokines in postmortem brains of patients with ASD. Considering the significant association between food, respiratory, and skin allergy in children with ASD reported by Xu and colleagues, in conjunction with numerous studies documenting aspects of immune dysfunction in patients with ASD and specific animal models of ASD, evidence continues to mount that an immune-mediated subtype of ASD should continue to be pursued and defined.”

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  • June 8, 2018
Autism Biomarkers / Autoimmunity / Cytokines / GI / Immune / Males / Parental reports / Review / Seizure

Association of Food Allergy and Other Allergic Conditions With Autism Spectrum Disorder in Children

CONCLUSIONS AND RELEVANCE In a nationally representative sample of US children, a significant and positive association of common allergic conditions, in particular food allergy, with ASD was found. Further investigation is warranted to elucidate the causality and underlying mechanism

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  • June 8, 2018

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